Neurological complications due COVID-19
Keywords:
Coronavirus infection, SARS-CoV-2, COVID-19, neurological complicationsAbstract
COVID-19 has been characterized by high morbidity and mortality with a varied clinical presentation due to the multi-organ involvement caused by SARS-CoV-2. Although the respiratory system is the most compromised, there is evidence that the virus can also invade the nervous system. Objective: To describe the state of the art on neurological complications related to COVID-19. A bibliographic review was carried out in the Infomed, Bibliomed, PubMed and Medline databases, until April 2022. General epidemiology and pathophysiological mechanisms of the neurological involvement of COVID-19 were investigated, as well as the main neurological complications of the disease. The keywords used for this review were coronavirus infection, SARS-CoV-2, COVID-19, neurological complications. SARS- CoV-2 is a beta-coronavirus that contains a single positive chain of RNA inside it and is transmitted mainly by the repiratory route. The neurological syndromes associated with the virus could be produced by direct infection of the nervous system or later in the form of demyelinating lesions due to infectious diseases. This clinical expression of the nervous system depends on the capabilities of neuroinvasion, neurotropism and neurovirulence of the coronavirus. Various pathogenic mechanisms have been proposed to explain the neurological involvement in COVID-19. An important element is the degree of expression of the receptor for the angiotensin-converting enzyme II in the nervous system. According to this, have been reported from mild neurological clinical forms to severe complications.Downloads
References
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