Importance of the inflammatory response in the perioperative period and its pharmacological modulation
Keywords:
neutrophil/lymphocyte ratio, pharmacological modulation with intravenous lidocaineAbstract
Introduction: During the surgical process of the cancer patient, an inflammatory response is generated, sometimes uncontrolled. This could modify the postoperative result.
Objective: To determine the influence of the inflammatory response in the postoperative result and the markers of greater value; as well as the influence of anesthetic drugs in its pharmacological modulation.
Methods: The available bibliography of the last 10 years was searched through Medline, Clinical Key, Pubmed, Scopus. Filters were initially used to review meta-analyses, systematic reviews, and other review studies.
Development: In cancer patients, several factors that trigger an inflammatory response coincide. This causes an increase in postoperative complications and tumor recurrence. There are several markers that predict this response; however, the neutrophil/lymphocyte ratio is the most feasible to perform and is attributed a high prognostic value when it rises above 5. Anesthetic drugs allow modulation of the inflammatory response, a notable effect for intravenous lidocaine and locoregional techniques.
Conclusions: Patients with a neutrophil/lymphocyte ratio above 5 have worse postoperative results and this can be modulated with intravenous lidocaine and the use of opioid-sparing techniques whenever possible.
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References
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