Multisystem inflammation syndrome after SARS-CoV2 infection
Keywords:
SARS-CoV2, pediatric population, multisystem inflammation syndromeAbstract
Introduction: Initially, SARS-CoV2 infection had low incidence in the pediatric population. Since the increase in the number of infants and research processes, a clinical disease called multisystem inflammation syndrome was found, which especially affected children and adolescents.
Objective: To characterize the multisystemic inflammation syndrome after SARS-CoV2 infection in the adolescent and pediatric population.
Case report: The first case of multisystemic inflammation syndrome is reported here. A male patient under 21 years of age was diagnosed at the Príncipe de Asturias University Hospital, and he required admission to the Intensive Care Unit. He showed a favorable clinical evolution after starting treatment, according to the recommendations established at that time for the treatment of this disease in the pediatric and adolescent population.
Conclusions: SARS-CoV2 infection equally affects children and adolescents. Although the multisystemic inflammation syndrome associated with SARS-CoV2 infection is included in the differential diagnosis of the main inflammatory conditions of childhood, further studies are necessary to assess the predisposing factors and the pathogenesis of MIS-C in order to prevent it, as it may be possible, and to optimize its treatment.
Downloads
References
1. Bertoncelli D, Guidarini M, Della Greca A, Ratti C, Falcinella F, Iovane B, et al. COVID19: potential cardiovascular issues in pediatric patients. Acta Biomed. 2020 May 11;91(2):177-83. Doi: 10.23750/abm.v91i2.9655.
2. Rigante D. Kawasaki disease as the immune-mediated echo of a viral infection. Mediterr J Hematol Infect Dis. 2020;12(1):e2020039. Doi: 10.4084/MJHID.2020.039.
3. Sánchez-Manubens J. Enfermedad de Kawasaki. Protoc diagn ter pediatr. 2020 [citado: 03/05/2021];2:213-24. Disponible en: https://www.aeped.es/sites/default/files/documentos/19_kawasaki.pdf
4. Nakra NA, Blumberg DA, Herrera-Guerra A, Lakshminrusimha S. Multi-System Inflammatory Syndrome in Children (MIS-C) following SARS-CoV-2 infection: review of clinical presentation, hypothetical pathogenesis, and proposed management. Children. 2020;7(7):69. Doi: 10.3390/children7070069.
5. Berthelot JM, Drouet L, Lioté F. Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway? Emerg Microbes Infect. 2020 Dec;9(1):1514-22. Doi: 10.1080/22221751.2020.1785336
